New,simple, and efficient method for the synthesis of N-substituted 4-trifluoromethyl-5-(alkan-1-ol)-pyridin-2(1H)-imines |
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| Authors: | Mário A Marangoni Carlos E Bencke Helio G Bonacorso Marcos AP Martins Nilo Zanatta |
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| Institution: | 1. Núcleo de Química de Heterociclos (NUQUIMHE), Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, Brazil;2. Laboratory of Chemistry, Instituto Federal Catarinense, 89240-000 São Francisco do Sul, SC, Brazil |
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| Abstract: | A new, simple, and efficient method for the synthesis a novel series of 1-substituted 4-(trifluoromethyl)-5-(alkan-1-ol)-pyridin-2(1H)-imines from the reaction of 3-(5,6-dihydro-4H-pyran-3-yl)-4,4,4-trifluorobut-2-enenitrile and 3-(4,5-dihydrofuran-3-yl)-4,4,4-trifluorobut-2-enenitrile with primary amines – is described. The products were obtained in 29–82% yield. |
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| Keywords: | 2-Pyridinimines 3 Pentadiene nitriles Horner-Wadsworth-Emmons olefination DTVXDUSVTCMEGR-UHFFFAOYSA-N |
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