Expanding available pyrazole substitution patterns by sydnone cycloaddition reactions |
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Authors: | A.W. Brown J.P.A. Harrity |
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Affiliation: | Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK |
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Abstract: | We report the use of alkynylsilanes for the regiocontrolled synthesis of pyrazoles from functionalised sydnones. The strategies outlined herein allow a range of pyrazoles to be accessed with substitution patterns that are otherwise not directly obtained with high selectivity by alkyne cycloadditions. Moreover, this study serendipitously highlighted a simple and convenient procedure for the synthesis of aryl monofluoromethyl ethers through the combination of TBAF and dichloromethane. |
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Keywords: | Sydnones Pyrazoles Regioselective Cycloaddition |
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