Mechanistic aspects of alkene oxidation using chiral hypervalent iodine reagents |
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Authors: | Morifumi Fujita |
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Affiliation: | Graduate School of Material Science, University of Hyogo, Kohto, Kamigori, Hyogo 678-1297, Japan |
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Abstract: | Recent progress in the area of hypervalent iodine-induced enantioselective oxidation is reviewed with emphasis from a mechanistic point of view. Chiral lactate and lactamide sidechains in hypervalent iodine reagents induce herical chirality around the iodine reaction site, which provides a chiral environment suitable for enantioselective transformations. The stereochemical outcomes of alkene oxidation are also compiled and used for systematically understanding the reaction mechanism of oxidative double bond difunctionalization. |
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Keywords: | Hypervalent iodine Asymmetric synthesis Oxidation Catalyst |
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