Nectrianolins A,B, and C,new metabolites produced by endophytic fungus Nectria pseudotrichia 120-1NP |
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| Authors: | Nanang Rudianto Ariefta Priska Kristiana Handojo Hadi Nurjanto Hiroyuki Momma Eunsang Kwon Tatsuya Ashitani Keitaro Tawaraya Tetsuya Murayama Takuya Koseki Hiroshi Furuno Narandulam Usukhbayar Ken-ichi Kimura Yoshihito Shiono |
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| Institution: | 1. The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan;2. Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan;3. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Bulaksumur, Yogyakarta 55281, Indonesia;4. Department of Silviculture, Faculty of Forestry, Universitas Gadjah Mada, Bulaksumur, Yogyakarta 55281, Indonesia;5. Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, Sendai, Miyagi 980-8576, Japan;6. Institute for Materials Chemistry and Engineering (IMCE), Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan |
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| Abstract: | Two sesquiterpene-epoxycyclohexenone conjugates, nectrianolins A (1) and B (2), together with a sesquiterpene, nectrianolin C (3), were isolated from the brown rice culture of Nectria pseudotrichia 120-1NP, an endophytic fungus isolated from Gliricidia sepium. Their structures were determined on the basis of 1D-/2D-NMR spectroscopy and HRESIMS data analyses in combination with chemical means. Nectrianolins A–C (1–3) exhibited cytotoxic activity against both HL60 and HeLa cells. |
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| Keywords: | Endophyte Cytotoxicity Nectrianolins |
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