A mild halogenation of pyrazoles using sodium halide salts and Oxone |
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| Authors: | Kathryn L. Olsen Matthew R. Jensen James A. MacKay |
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| Affiliation: | Department of Chemistry and Biochemistry, Elizabethtown College, 1 Alpha Drive, Elizabethtown, PA, United States |
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| Abstract: | A mild, inexpensive, and operationally simple pyrazole halogenation method utilizing Oxone and sodium halide salts is reported. This work documents 17 examples of alkyl, aryl, allyl, and benzyl substituted 4-chloro and 4-bromopyrazoles, obtained in up to 93% yield. Reactions are performed in water under ambient conditions and generation of organic byproducts is avoided. |
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| Keywords: | Pyrazole Halogenation Oxone Green chemistry |
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