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Synthesis of bicyclic tripeptides inspired by the ABC-ring system of vancomycin through ruthenium-based cyclization chemistries |
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| Authors: | Xin Yang Lucas P. Beroske Johan Kemmink Dirk T.S. Rijkers Rob M.J. Liskamp |
| Affiliation: | 1. Division of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands;2. School of Chemistry, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ, United Kingdom |
| Abstract: | The synthesis of a bicyclic tripeptide that mimics the ABC ring system of vancomycin is described by using a ring closing metathesis (RCM) – peptide coupling – ruthenium-catalyzed azide-alkyne cycloaddition (RuAAC) strategy. |
| Keywords: | Macrocycles Peptides Peptidomimetics Ring-closing metathesis Ru-based azide-alkyne cycloaddition |
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