| 新型尾式多肽卟啉的合成与光谱性质研究 |
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| 引用本文： | 薛珺,曾婷,王亚军,罗国添. 新型尾式多肽卟啉的合成与光谱性质研究[J]. 化学通报, 2012, 0(6): 547-551 |
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| 作者姓名： | 薛珺 曾婷 王亚军 罗国添 |
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| 作者单位： | 赣南师范学院化学化工学院;江西省有机药物化学重点实验室 |
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| 基金项目： | 国家自然科学基金项目(20761001,21161001);江西省教育厅科技基金项目(GJJ11588)资助 |
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| 摘 要： | 以5-(4-氨基苯基)-10,15,20-三苯基卟啉和叔丁氧羰基(Boc)保护的氨基酸为原料,合成了3种新型尾式多肽卟啉。通过FT-IR,FAB-MS,1H NMR,UV-Vis及元素分析对产物进行了表征并研究了其光谱性质。结果表明,所合成的尾式多肽卟啉产率高达90%以上,在位于可见光红光区的650nm附近均具有较强的荧光发射,符合光敏剂在光学方面的要求,有望成为新型潜在的具有靶向作用的光敏剂。
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| 关 键 词： | 尾式多肽卟啉 合成 光谱性质 |
Synthesis and Spectral Properties of Novel Tailed Porphrin Polypeptides |
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| Xue Jun,Zeng Ting,Wang Yajun,Luo Guotian. Synthesis and Spectral Properties of Novel Tailed Porphrin Polypeptides[J]. Chemistry, 2012, 0(6): 547-551 |
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| Authors: | Xue Jun Zeng Ting Wang Yajun Luo Guotian |
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| Affiliation: | 1,2(1College of Chemistry and Chemical Engineering,Gannan Normal University,Ganzhou 341000; 2Key Laboratory of Organo-Pharmaceutical Chemistry,Jiangxi Province,Ganzhou 341000) |
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| Abstract: | Three novel tailed porphyrin polypeptides were designed and synthesized by the reaction of 5-(4-aminophenyl)-10,15,20-triphenylporphyrin with amino acids protected with tert-butoxycarbonyl(Boc).The as-prepared compounds were characterized by FT-IR,FAB-MS,1H NMR,UV-Vis and element analysis.The products exhibited strong fluorescence emit at near 650 nm.That means they meet the requirements of photosensitizer used in the optical field,and is expected to become a potential targeting photosensitizer. |
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| Keywords: | Tailed porphyrin polypeptides Synthesis Spectral properties |
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