Studies on the chemistry of thienoannelated O,N‐ and S,N‐containing heterocycles. 25. Synthesis of new imidazolyl and pyrazolyl derivatives of thiophene as inhibitors of nitric oxide synthase

Some novel imidazolyl and pyrazolyl thiophene derivatives were synthesized. Different substituted N‐containing heterocycles were chosen with the aim of enhancing the activity or selectivity of the products towards inhibition of one of the three isoforms of nitric oxide synthase. One series of substances was prepared by substitution reactions of 3‐bromo‐2‐nitrothiophene with various heterocycles. In the other series introduction of a second heterocyclic substituent to pyrazolylthiophene compounds was attempted.