| Abstract: | The application of the randomly optimized RDSQC (Randomly optimized Direct correlation Single Quantum Coherence) experiment for the detection of direct correlations facilitated the characterization of an unknown compound. The expected structure consisted of purely aliphatic moieties. The actual, identified compound contained the desired structure plus an adenosine functionality with two protons whose direct proton‐carbon couplings were over 200 Hz. Application of a 130 Hz optimized direct heteronuclear GHSQC experiment afforded no correlations for the adenine responses. The RDSQC experiment allowed for the simultaneous optimization of multiple couplings in a range of 130 to 220 Hz producing a direct correlation spectrum with all the expected responses. |
