| 重水在咪唑N-烷基化相转移催化反应中的影响 |
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| 引用本文： | 刘汉明,袁承业.重水在咪唑N-烷基化相转移催化反应中的影响[J].化学学报,1987,45(8):791-793. |
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| 作者姓名： | 刘汉明 袁承业 |
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| 作者单位： | 中国科学院上海有机化学研究所 |
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| 摘 要： | 咪唑及其衍生物在相转移催化剂(PTC)存在下和烷基卤进行N-烷基化反应能得到较好的结果,但重水在此反应中的影响,至今未见文献记载.作者为进一步探讨在相转移催化剂存在下吡唑、咪唑及其衍生物N-烷基化反应机制,采用重水作为相转移反应体系的水相,观察其对反应的影响.
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| 关 键 词： | 咪唑P 反应机理 重水 浓度 烷基化 活化能 反应速度常数 Ｎ-烷基 水相 相移转催化 |
The effect of heavy water on phase transfer catalytic N-alkylation of imidazole and its derivatives |
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| LIU HANMING,YUAN CHENGYE.The effect of heavy water on phase transfer catalytic N-alkylation of imidazole and its derivatives[J].Acta Chimica Sinica,1987,45(8):791-793. |
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| Authors: | LIU HANMING YUAN CHENGYE |
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| Abstract: | The effect of heavy water on N-alkylation of imidazole and its derivatives under phase transfer catalytic condition was discussed. It is demonstrated that heavy water shows significant solvent isotope effect, associated with the increase of basicity of imidazole and pyrazole. The reaction rate of N-n-butylation in PTC in H2O and D2O were determine |
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| Keywords: | IMIDAZOLE P REACTION MECHANISM HEAVY WATER CONCENTRATION ALKYLATION ACTIVATION ENERGY REACTION RATE CONSTANT N-ALKYL GROUP WATER PHASE PHASE TRANSFER CATALYSIS |
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