N-arylation of primary and secondary aliphatic amines on solid supports |
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| Authors: | Combs Andrew P Tadesse Seifu Rafalski Maria Haque Tasir S Lam Patrick Y S |
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| Institution: | Chemical and Physical Sciences Department, DuPont Pharmaceuticals Company, Experimental Station, P.O. Box 80500, Wilmington, Delaware 19880-0500, USA. |
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| Abstract: | A general and mild method for the N-arylation of primary and secondary aliphatic amines is reported. Copper acetate, triethylamine mediated C/N cross-coupling reaction of arylboronic acids at room temperature to solid-supported primary and secondary amines gave good to excellent yields of the desired N-arylated products. |
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