| 新型联吡啶配体P-Phos在钯催化胺偶联反应中的应用 |
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| 引用本文： | 陈欢生,王全瑞,陶凤岗.新型联吡啶配体P-Phos在钯催化胺偶联反应中的应用[J].中国化学,2009,27(7):1382-1386. |
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| 作者姓名： | 陈欢生 王全瑞 陶凤岗 |
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| 作者单位： | 复旦大学化学系上海200433 |
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| 摘 要： | P-Phos 2,2′6,6′-四甲氧基吡啶-4,4′-二(二苯基膦)-3,3′-联吡啶]是一类对空气稳定的杂环磷配体。本文以较简单的方法合成了rac-P-Phos配体，并用IR、1H NMR、13C NMR和元素分析等方法进行了表征。首次将P-Phos配体用于催化卤代芳烃和胺的偶联反应中。通过对碱、溶剂和催化剂用量等的筛选，确立了最优化的反应条件。配体对溴代芳烃的催化效果很好，对具有吸电子存在的氯代芳烃，特别是氯代吡啶同样得到了令人满意的结果，分离产率高达97％。催化剂对水和空气的稳定性很好，对胺偶联反应的催化效果很理想，因此是一种有应用前景的催化剂。
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| 关 键 词： | Buchwald-Hartwig胺偶联反应 rac-P-Phos 钯催化 芳香胺 |
| 收稿时间： | 2008-10-19 |
| 修稿时间： | 2009-2-21 |
A Novel Palladium‐catalyzed Amination of Aryl Halides with Amines Using rac‐P‐Phos as the Ligand |
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| Huansheng CHEN,Quanrui WANG,Fenggang TAO.A Novel Palladium‐catalyzed Amination of Aryl Halides with Amines Using rac‐P‐Phos as the Ligand[J].Chinese Journal of Chemistry,2009,27(7):1382-1386. |
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| Authors: | Huansheng CHEN Quanrui WANG Fenggang TAO |
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| Institution: | 1. Department of Chemistry, Fudan University, Shanghai 200433, China;2. Tel.: 0086‐021‐65643978;3. Fax: 0086‐021‐65641740 |
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| Abstract: | An efficient palladium‐catalyzed amination of aryl halides with amines, using rac‐P‐Phos as the ancillary ligand and Pd(OAc)2 as the palladium source is developed. The ligand and all of the synthetic intermediates are stable to air and moisture, allowing the easy handling. The catalyst system performed well for a large number of different substrate combinations in 80–110°C to furnish aromatic amines in high yields. |
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| Keywords: | Buchwald‐Hartwig amination rac‐P‐Phos palladium aromatic amine |
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