| N-取代-2-氯乙酰胺合成方法的改进及表征 |
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| 引用本文： | 赵华绒,朱婷婷. N-取代-2-氯乙酰胺合成方法的改进及表征[J]. 浙江大学学报(理学版), 2010, 37(4): 442-445. DOI: 10.3785/j.issn.1008-9497.2010.04.017 |
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| 作者姓名： | 赵华绒 朱婷婷 |
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| 作者单位： | 浙江大学,化学系,浙江,杭州,310027 |
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| 基金项目： | 浙江省自然科学基金资助项目 |
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| 摘 要： | 对N-取代-2-氯乙酰胺的合成方法进行了详细研究并提出了改进方法:在Et3N/CH2Cl2体系中,各种胺与氯乙酰氯以物质的量之比为1∶1.2的比例投入,在室温下反应20 min,可定量得到相应的N-取代-2-氯乙酰胺.产物结构经IR、1H NMR和MS表征.
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| 关 键 词： | 胺 氯乙酰氯 N-取代-2-氯乙酰胺 合成 |
Synthetic Improvement and Charaterization of N-Substituted-2-Chloroacetamides |
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| ZHAO Hua-rong,ZHU Ting-ting. Synthetic Improvement and Charaterization of N-Substituted-2-Chloroacetamides[J]. Journal of Zhejiang University(Sciences Edition), 2010, 37(4): 442-445. DOI: 10.3785/j.issn.1008-9497.2010.04.017 |
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| Authors: | ZHAO Hua-rong ZHU Ting-ting |
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| Affiliation: | (Department of Chemistry,Zhejiang University,Hangzhou 310027,China) |
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| Abstract: | Here a detailed and improved route to N-substituted-2-chloroacetamides was provided.A variety of substituted amines reacted with chloroacetyl chloride in 1∶1.2 molar ratio in CH2Cl2/Et3N system at room temperature for 20 min to form corresponding N-substituted-2-chloroacetamides.The yield of reaction was almost 100%.All compounds were characterized by IR,1H NMR and MS techniques. |
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| Keywords: | amines chloroacetyl chloride N-substituted chloroacetamides synthesis |
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