Double CF Bond Activation through β‐Fluorine Elimination: Nickel‐Mediated [3+2] Cycloaddition of 2‐Trifluoromethyl‐1‐alkenes with Alkynes |
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| Authors: | Tomohiro Ichitsuka Dr. Takeshi Fujita Tomohiro Arita Prof. Dr. Junji Ichikawa |
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| Affiliation: | Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305‐8571 (Japan) http://www.chem.tsukuba.ac.jp/junji/index.html |
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| Abstract: | The nickel‐mediated [3+2] cycloaddition of 2‐trifluoromethyl‐1‐alkenes with alkynes afforded fluorine‐containing multi‐substituted cyclopentadienes in a regioselective manner. This reaction involves the consecutive two C? F bond cleavage of a trifluoromethyl or a pentafluoroethyl group through β‐fluorine elimination. |
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| Keywords: | alkynes C F bond activation cycloaddition cyclopentadienes fluoroalkenes nickel |
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