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Catalytic Enantioselective CH Functionalization of Alcohols by Redox‐Triggered Carbonyl Addition: Borrowing Hydrogen,Returning Carbon
Authors:John M. Ketcham  Inji Shin  T. Patrick Montgomery  Prof. Michael J. Krische
Affiliation:University of Texas at Austin, Department of Chemistry and Biochemistry, 1 University Station ‐ A5300, Austin, TX 78712‐1167 (USA)
Abstract:The use of alcohols and unsaturated reactants for the redox‐triggered generation of nucleophile–electrophile pairs represents a broad, new approach to carbonyl addition chemistry. Discrete redox manipulations that are often required for the generation of carbonyl electrophiles and premetalated carbon‐centered nucleophiles are thus avoided. Based on this concept, a broad, new family of enantioselective C? C coupling reactions that are catalyzed by iridium or ruthenium complexes have been developed, which are summarized in this Minireview.
Keywords:enantioselective catalysis  iridium  polyketide natural products  ruthenium  transfer hydrogenation
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