Palladium‐Catalyzed Asymmetric Amination of Allenyl Phosphates: Enantioselective Synthesis of Allenes with an Additional Unsaturated Unit |
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| Authors: | Qiankun Li Prof?Dr Chunling Fu Prof?Dr Shengming Ma |
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| Institution: | Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang (P.R. China) |
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| Abstract: | A highly enantioselective Pd‐catalyzed amination of allenyl phosphates generating 2,3‐allenyl amines with central chirality has been developed. Under the optimized conditions, chiral 2,3‐allenyl amines with or without (an) additional C? C double or triple bond(s) have been prepared at 0 °C with up to 90 % yield and 94 % ee by identifying (R)‐3,4,5‐(MeO)3‐MeOBIPHEP as the ligand. |
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| Keywords: | allenes amination asymmetric allenylation central chirality palladium |
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