Metal‐Free Annulation of Arenes with 2‐Aminopyridine Derivatives: The Methyl Group as a Traceless Non‐Chelating Directing Group |
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| Authors: | Srimanta Manna Dr Kiran Matcha Dr Andrey P Antonchick |
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| Institution: | 1. Abteilung Chemische Biologie, Max‐Planck‐Institut für Molekulare Physiologie, Otto‐Hahn‐Strasse 11, 44227 Dortmund (Germany);2. Fakult?t Chemie und Chemische Biologie, Technische Universit?t Dortmund, Otto‐Hahn‐Strasse 6, 44221 Dortmund (Germany);3. Fakult?t Chemie und Chemische Biologie, Technische Universit?t Dortmund, Otto‐Hahn‐Strasse 6, 44221 Dortmund (Germany)Abteilung Chemische Biologie, Max‐Planck‐Institut für Molekulare Physiologie, Otto‐Hahn‐Strasse 11, 44227 Dortmund (Germany)=== |
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| Abstract: | A novel annulation reaction between 2‐aminopyridine derivatives and arenes under metal‐free conditions is described. The presented intermolecular transformation provided straightforward access to the important pyrido1,2‐a]benzimidazole scaffold under mild reaction conditions. The unprecedented application of the methyl group of methylbenzenes as a traceless, non‐chelating, and highly regioselective directing group is reported. |
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| Keywords: | annulation benzimidazoles C H amination hypervalent iodine reagents metal‐free reactions |
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