Enantioselective NH Insertion Reaction of α‐Aryl α‐Diazoketones: An Efficient Route to Chiral α‐Aminoketones |
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| Authors: | Bin Xu Prof. Shou‐Fei Zhu Xiao‐Dong Zuo Zhi‐Chao Zhang Prof. Qi‐Lin Zhou |
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| Affiliation: | 1. State Key Laboratory and Institute of Elemento‐organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn/;2. Collaborative Innovation Center of Chemical Science and Engineering, Tianjin (China) |
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| Abstract: | A highly enantioselective N? H insertion reaction of α‐diazoketones was developed by using cooperative catalysis by dirhodium(II) carboxylates and chiral spiro phosphoric acids. The insertion reaction provides a new access route to diverse chiral α‐aminoketones, which are versatile building blocks in organic synthesis, with fast reaction rates, good yields and high enantioselectivity under mild and neutral conditions. |
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| Keywords: | asymmetric catalysis carbenes chiral proton shuttle chiral α ‐aminoketones diazo compounds |
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