Metal‐Free Photochemical Aromatic Perfluoroalkylation of α‐Cyano Arylacetates |
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| Authors: | Manuel Nappi Dr Giulia Bergonzini Prof Dr Paolo Melchiorre |
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| Institution: | 1. ICIQ—Institute of Chemical Research of Catalonia, Avenida Pa?sos Catalans 16, 43007 Tarragona (Spain) http://www.iciq.es/portal/862/default.aspx;2. ICREA—Institució Catalana de Recerca i Estudis Avan?ats, Passeig Lluís Companys 23, 08010 Barcelona (Spain) |
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| Abstract: | We report here an operationally simple protocol for the direct aromatic perfluoroalkylation and trifluoromethylation of α‐cyano arylacetates. This metal‐free approach, which occurs at ambient temperature and under visible‐light irradiation, is driven by the photochemical activity of electron donor–acceptor (EDA) complexes, formed in situ by the interaction of transiently generated enolates and perfluoroalkyl iodides. Preliminary mechanistic studies are reported. |
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| Keywords: | C H functionalization perfluoroalkylation photochemistry synthetic methods trifluoromethylation |
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