A Bioinspired Catalytic Oxygenase Cascade to Generate Complex Oxindoles |
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| Authors: | Dr Yao Wang Dipl‐Chem Jonathan O Bauer Prof Dr Carsten Strohmann Dr Kamal Kumar |
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| Institution: | 1. Max‐Planck‐Institut für molekulare Physiologie, Otto‐Hahn‐Strasse 11, 44227 Dortmund (Germany) http://www.mpi‐dortmund.mpg.de/74401/Kumar;2. Technische Universit?t Dortmund, Fakult?t Chemie, Anorganische Chemie, Otto‐Hahn‐Strasse 6, 44221 Dortmund (Germany);3. Technische Universit?t Dortmund, Fachbereich Chemie, Chemische Biologie, 44221 Dortmund (Germany) |
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| Abstract: | Catalytic, selective, and controlled oxidative functionalization of C? H bonds using molecular oxygen as an oxidant remains highly desirable and equally challenging in the development of synthetic methodologies. Presented herein is a one‐pot oxygenase cascade reaction wherein a copper(I)‐catalyzed oxygenase reaction transforms the allylic methyl group in 3‐methylidene oxindoles into an aldehyde, which then undergoes an aldol–oxa‐Michael addition sequence with β‐ketoesters to yield dihydrofuran‐bearing oxindoles. |
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| Keywords: | allylic compounds bioinspired catalysis copper heterocycles oxidation |
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