Palladium‐Catalyzed Heck‐Type Cross‐Couplings of Unactivated Alkyl Iodides |
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| Authors: | Caitlin M McMahon Prof Erik J Alexanian |
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| Institution: | Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (USA) |
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| Abstract: | A palladium‐catalyzed, intermolecular Heck‐type coupling of alkyl iodides and alkenes is described. This process is successful with a variety of primary and secondary unactivated alkyl iodides as reaction partners, including those with hydrogen atoms in the β position. The mild catalytic conditions enable intermolecular C? C bond formations with a diverse set of alkyl iodides and alkenes, including substrates containing base‐ or nucleophile‐sensitive functionality. |
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| Keywords: | alkenes alkyl halides cross‐coupling homogeneous catalysis palladium |
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