Omaezallene from Red Alga Laurencia sp.: Structure Elucidation,Total Synthesis,and Antifouling Activity |
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| Authors: | Dr Taiki Umezawa Yuko Oguri Dr Hiroshi Matsuura Shohei Yamazaki Masahiro Suzuki Erina Yoshimura Dr Takeshi Furuta Dr Yasuyuki Nogata Dr Yukihiko Serisawa Dr Kazuyo Matsuyama‐Serisawa Dr Tsuyoshi Abe Prof Dr Fuyuhiko Matsuda Dr Minoru Suzuki Dr Tatsufumi Okino |
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| Institution: | 1. Graduate School of Environmental Science, Hokkaido University, Sapporo 060‐0810 (Japan);2. CERES, Inc. 1‐6‐1 Ogawa‐cho, Kanda, Chiyoda‐ku, Tokyo 101‐0052 (Japan);3. Environmental Science Research Laboratory, Central Research Institute of Electric Power Industry, Abiko 270‐1194 (Japan);4. Faculty of Education and Human Sciences, University of Yamanashi, Kofu 400‐8510 (Japan);5. The Hokkaido University Museum, Hokkaido University, Sapporo 060‐0810 (Japan) |
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| Abstract: | Natural antifouling products have been the subject of considerable attention. We screened marine algae for antifouling activity and discovered omaezallenes, the new bromoallene‐containing natural products isolated from the red alga Laurencia sp. Described is the isolation, structure elucidation, and total syntheses of omaezallenes. The relative and absolute configurations of natural omaezallenes were unambiguously established through total synthesis. The antifouling activities and ecotoxicity of omaezallenes were also evaluated. |
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| Keywords: | allenes antifouling natural products structure elucidation total synthesis |
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