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Asymmetric Catalysis on the Nanoscale: The Organocatalytic Approach to Helicenes |
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| Authors: | Lisa Kötzner Dr Matthew J Webber Dr Alberto Martínez Dr Claudia De?Fusco Prof?Dr Benjamin List |
| Institution: | Max‐Planck‐Institut für Kohlenforschung, Kaiser Wilhelm‐Platz 1, 45470 Mülheim an der Ruhr (Germany) |
| Abstract: | The first asymmetric organocatalytic synthesis of helicenes is reported. A novel SPINOL‐derived phosphoric acid, bearing extended π‐substituents, catalyzes the asymmetric synthesis of helicenes through an enantioselective Fischer indole reaction. A variety of azahelicenes and diazahelicenes could be obtained with good to excellent yields and enantioselectivities. |
| Keywords: | Brø nsted acid catalysis Fischer indole synthesis helicenes organocatalysis |