Rhodium‐Catalyzed Asymmetric Arylation of β,γ‐Unsaturated α‐Ketoamides for the Construction of Nonracemic γ,γ‐Diarylcarbonyl Compounds |
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| Authors: | Dr. Juanjuan Wang Dr. Min Wang Prof. Dr. Peng Cao Liyin Jiang Dr. Guihua Chen Prof. Dr. Jian Liao |
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| Affiliation: | 1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041 (China);2. University of Chinese Academy of Sciences, Beijing 100049 (China);3. Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041 (China);4. College of Chemical Engineering, Sichuan University (China) |
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| Abstract: | A highly regio‐ and enantioselective rhodium‐catalyzed 1,4‐addition of arylboronic acids to β,γ‐unsaturated α‐ketoamides using a simple new chiral sulfinylphosphine ligand is described. This transformation provides an attractive approach to construct chiral nonracemic γ,γ‐diarylsubstituted carbonyl compounds, as exemplified in the concise syntheses of sertraline and tetrahydroquinoline‐2‐carboxylamide. |
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| Keywords: | asymmetric synthesis enantioselectivity homogeneous catalysis rhodium S,P ligands |
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