Suffrutines A and B: A Pair of Z/E Isomeric Indolizidine Alkaloids from the Roots of Flueggea suffruticosa |
| |
| Authors: | Zhen‐Long Wu Dr. Bing‐Xin Zhao Dr. Xiao‐Jun Huang Gen‐Yun Tang Dr. Lei Shi Prof. Dr. Ren‐Wang Jiang Xin Liu Dr. Ying Wang Prof. Dr. Wen‐Cai Ye |
| |
| Affiliation: | 1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, 510632 Guangzhou (China);2. JNU‐HKUST Joint Laboratory for Neuroscience & Innovation Drug Research, Jinan University, 510632 Guangzhou (China) |
| |
| Abstract: | Suffrutines A ( 1 ) and B ( 2 ), a pair of novel photochemical Z/E isomeric indolizidine alkaloids, with a unique and highly conjugated C20 skeleton, were isolated from the roots of Flueggea suffruticosa. The structures were elucidated by extensive analysis of NMR spectra and single‐crystal X‐ray diffraction. The light‐induced isomerization and hypothetical biogenetic pathway to 1 and 2 , as well as their activity for regulating the morphology of Neuro‐2a cells are also discussed. |
| |
| Keywords: | alkaloids natural products NMR spectroscopy photochemistry structure elucidation |
|
|
