Mimicking Biological Membranes with Programmable Glycan Ligands Self‐Assembled from Amphiphilic Janus Glycodendrimers |
| |
| Authors: | Dr Shaodong Zhang Dr Ralph‐Olivier Moussodia Dr Hao‐Jan Sun Dr Pawaret Leowanawat Adam Muncan Christopher D Nusbaum Kathleen M Chelling Prof?Dr Paul A Heiney Prof?Dr Michael L Klein Priv‐Doz?Dr Sabine André Prof?Dr René Roy Prof?Dr Hans‐J Gabius Prof?Dr Virgil Percec |
| |
| Institution: | 1. Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104‐6323 (USA) http://percec02.chem.upenn.edu/;2. Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104‐6396 (USA);3. Institute for Computational Molecular Science, Temple University, Philadelphia, PA 19122 (USA);4. Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig‐Maximilians‐University, 80539 Munich (Germany);5. Department of Chemistry, Université du Québec à Montréal, Montréal, Québec, H3C 3P8 (Canada) |
| |
| Abstract: | An accelerated modular synthesis produced 18 amphiphilic Janus glycodendrimers with three different topologies formed from either two or one carbohydrate head groups or a mixed constellation with a noncarbohydrate hydrophilic arm. By simple injection of their THF solutions into water or buffer, all of the Janus compounds self‐assembled into uniform, stable, and soft unilamellar vesicles, denoted glycodendrimersomes. The mixed constellation topology glycodendrimersomes were demonstrated to be most efficient in binding plant, bacterial, and human lectins. This evidence with biomedically relevant receptors offers a promising perspective for the application of such glycodendrimersomes in targeted drug delivery, vaccines, and other areas of nanomedicine. |
| |
| Keywords: | agglutinins biomembrane glycans dendrimers lectins vesicles |
|
|
