Copper‐Catalyzed Regioselective ortho CH Cyanation of Vinylarenes |
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| Authors: | Yang Yang Prof Dr Stephen L Buchwald |
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| Institution: | Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA) |
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| Abstract: | A copper‐based catalytic technique for the regioselective ortho C? H cyanation of vinylarenes has been developed. This method provides an effective means for the selective functionalization of vinylarene derivatives. A copper‐catalyzed cyanative dearomatization mechanism is proposed to account for the regiochemical course of this reaction. |
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| Keywords: | C H activation copper dearomatization ligand design synthetic methods |
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