Enantioselective Total Synthesis of (−)‐Lansai B and (+)‐Nocardioazines A and B |
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| Authors: | Haoxuan Wang Prof Sarah E Reisman |
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| Institution: | The Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 (USA) http://reismangroup.caltech.edu |
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| Abstract: | The concise total syntheses of the bis(pyrroloindolines) (?)‐lansai B and (+)‐ nocardioazines A and B are reported. The key pyrroloindoline building blocks are rapidly prepared by enantioselective formal 3+2] cycloaddition reactions. The macrocycle of (+)‐nocardioazine A is constructed by an unusual intramolecular diketopiperazine formation. |
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| Keywords: | cycloaddition heterocycles macrocycles natural products total synthesis |
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