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Visible‐Light‐Induced Formal [3+2] Cycloaddition for Pyrrole Synthesis under Metal‐Free Conditions |
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| Authors: | Jun Xuan Xu‐Dong Xia Ting‐Ting Zeng Zhu‐Jia Feng Prof. Dr. Jia‐Rong Chen Dr. Liang‐Qiu Lu Prof. Dr. Wen‐Jing Xiao |
| Affiliation: | 1. CCNU–uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan, Hubei 430079 (China) http://chem‐xiao.ccnu.edu.cn/;2. Collaborative Innovation Center of Chemical Science and Engineering, Tianjin (China);3. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, CAS (China) |
| Abstract: | A photocatalytic formal [3+2] cycloaddition of 2H‐azirines with alkynes has been achieved under irradiation by visible light in the presence of organic dye photocatalysts. This transformation provides efficient access to highly functionalized pyrroles in good yields and has been applied to the synthesis of drug analogues. A primary trial of photocascade catalysis merging energy transfer and redox neutral reactions was shown to be successful. |
| Keywords: | cycloaddition dyes heterocycles photochemistry synthetic methods |