Deactivation of Cationic CuI and AuI Catalysts for A3 Coupling by CH2Cl2: Mechanistic Implications of the Formation of Neutral CuI and AuI Chlorides |
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| Authors: | Dr Abdessamad Grirrane Dr Eleuterio Álvarez Prof?Dr Hermenegildo García Prof?Dr Avelino Corma |
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| Institution: | 1. Instituto Universitario de Tecnología Química CSIC‐UPV, Universidad Politécnica de Valencia, Av. de los Naranjos s/n, 46022 Valencia (Spain);2. Instituto de Investigaciones Químicas CSIC‐US, Departamento de Química Inorgánica, Av. Américo Vespucio 49, 41092 Sevilla (Spain) |
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| Abstract: | Care should be exercised when using CH2Cl2 as a solvent for reactions in which amines are a reagent, since undesirable deactivation of cationic copper(I) and gold(I) catalysts to form the corresponding inactive neutral chloride complexes LMCl] (M=Cu or Au) can occur as a result of the generation of hydrogen chloride in the medium. CuI and AuI deactivation has been proved for the Mannich three‐component coupling reaction. A series of CuI and AuI complexes with potential mechanistic implications were isolated and characterized by X‐ray crystallography. |
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| Keywords: | coordination chemistry copper intermediates gold intermediates homogeneous catalysis propargylamines |
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