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Spontaneous Biomimetic Formation of (±)‐Dictazole B under Irradiation with Artificial Sunlight |
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| Authors: | Adam Skiredj Dr. Mehdi A. Beniddir Prof. Dr. Delphine Joseph Karine Leblanc Dr. Guillaume Bernadat Dr. Laurent Evanno Prof. Dr. Erwan Poupon |
| Affiliation: | 1. Laboratoire de Pharmacognosie associé au CNRS, UMR 8076 BioCIS, LabEx LERMIT, Université Paris‐Sud, 5, rue Jean‐Baptiste Clément, 92296 Chatenay‐Malabry (France) http://www.biocis.u‐psud.fr;2. équipe “Molécules fluorées et chimie médicinale” UMR 8076 BioCIS, LabEx LERMIT, Université Paris‐Sud, 5, rue Jean‐Baptiste Clément, 92296 Chatenay‐Malabry (France) |
| Abstract: | Guided by biosynthetic considerations, the total synthesis of dictazole B is reported for the first time. Experimental evidence for an easy access to challenging cyclobutane alkaloids of marine origin, which are often postulated to be biosynthetic precursors of more complex structures, is provided. |
| Keywords: | alkaloids aplysinopsin biomimetic synthesis natural products self‐assembly |