Hexacoordinate Nickel(II)/(III) Complexes that Mimic the Catalytic Cycle of Nickel Superoxide Dismutase |
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| Authors: | Sudip K Chatterjee Ram Chandra Maji Suman Kumar Barman Prof?Dr Marilyn M Olmstead Dr Apurba K Patra |
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| Institution: | 1. Department of Chemistry, National Institute of Technology Durgapur, Mahatma Gandhi Avenue, Durgapur 713 209 (WB) (India);2. Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208 016 (India);3. Department of Chemistry, University of California, Davis, CA 95616 (USA) |
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| Abstract: | A functional model complex of nickel superoxide dismutase (NiSOD) with a non‐peptide ligand which mimics the full catalytic cycle of NiSOD is unknown. Similarly, it has not been fully elucidated whether NiSOD activity is a result of an outer‐ or inner‐sphere electron‐transfer mechanism. With this in mind, two octahedral nickel(II)/(III) complexes of a bis‐tridentate N2S donor carboxamide ligand, N‐2‐phenylthiophenyl‐2′‐pyridinecarboxamide (HLPh), have been synthesized, structurally characterized, and their SOD activities examined. These complexes mimic the full catalytic cycle of NiSOD. Electrochemical experiments support an outer‐sphere electron‐transfer mechanism for their SOD activity. |
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| Keywords: | electrochemistry enzyme models nickel outer‐sphere electron transfer X‐ray diffraction |
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