Access to Oxoquinoline Heterocycles by N‐Heterocyclic Carbene Catalyzed Ester Activation for Selective Reaction with an Enone |
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| Authors: | Dr. Zhenqian Fu Dr. Ke Jiang Dr. Tingshun Zhu Prof. Dr. Jaume Torres Prof. Dr. Yonggui Robin Chi |
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| Affiliation: | 1. Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore);2. School of Biological Sciences, Nanyang Technological University, Singapore 637371 (Singapore) |
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| Abstract: | Organocatalytic ester activation is developed for a highly selective cascade reaction between saturated esters and amino enones. The reaction involves activation of the β‐carbon atom of the ester as a key step. This method allows a single‐step access to multicyclic oxoquinoline‐type heterocycles with high enantiomeric ratios. |
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| Keywords: | C H activation cyclization heterocycles N‐heterocyclic carbene organocatalysis |
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