Direct Assembly of 3,4‐Difunctionalized Benzofurans and Polycyclic Benzofurans by Phenol Dearomatization and Palladium‐Catalyzed Domino Reaction |
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| Authors: | Zhaomeng Han Liang Zhang Prof. Dr. Zhiming Li Prof. Dr. Renhua Fan |
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| Affiliation: | Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433 (China) |
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| Abstract: | A method to directly convert 2‐alkynylphenols to 3,4‐difunctionalized benzofurans and polycyclic benzofurans was developed. This protocol involves a hypervalent‐iodine‐mediated oxidative dearomatization to break the aromaticity of 2‐alkynylphenols, and a palladium‐catalyzed domino reaction to install two functional groups at the C3 and the C4 positions and restore the aromaticity of benzofurans. |
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| Keywords: | benzofurans dearomatization domino reactions multicomponent reactions phenols |
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