Cationic Ir/Me‐BIPAM‐Catalyzed Asymmetric Intramolecular Direct Hydroarylation of α‐Ketoamides |
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| Authors: | Tomohiko Shirai Prof?Dr Hajime Ito Prof?Dr Yasunori Yamamoto |
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| Institution: | Division of Chemical Process Engineering and Frontier Chemistry Center (FCC), Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8 Kita‐ku, Sapporo, Hokkaido 060‐8628 (Japan) |
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| Abstract: | Asymmetric intramolecular direct hydroarylation of α‐ketoamides gives various types of optically active 3‐substituted 3‐hydroxy‐2‐oxindoles in high yields with complete regioselectivity and high enantioselectivities (84–98 % ee). This is realized by the use of the cationic iridium complex Ir(cod)2](BArF4) and the chiral O‐linked bidentate phosphoramidite (R,R)‐Me‐BIPAM. |
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| Keywords: | asymmetric catalysis C‐H functionalization iridium oxindoles phosphoramidites |
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