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A Cyclization–Rearrangement Cascade for the Synthesis of Structurally Complex Chiral Gold(I)–Aminocarbene Complexes |
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| Authors: | Dr Filip Kolund?i? Dr Annamalai Murali Dr Patricia Pérez‐Galán Dipl‐Chem Jonathan O Bauer Prof?Dr Carsten Strohmann Dr Kamal Kumar Prof?Dr Herbert Waldmann |
| Institution: | 1. Max‐Planck‐Institut für molekulare Physiologie, Otto‐Hahn‐Strasse 11, 44227 Dortmund (Germany);2. Technische Universit?t Dortmund, Fakult?t Chemie, Anorganische Chemie, Otto‐Hahn‐Strasse 6, 44221 Dortmund (Germany);3. Technische Universit?t Dortmund, Fachbereich Chemie, 44221 Dortmund (Germany) |
| Abstract: | A facile synthesis of chiral cyclic alkyl aminocarbene–gold(I) complexes from gold‐free 1,7‐enyne substrates was developed. The novel cyclization–rearrangement reaction sequence is triggered by the addition of (Me2S)AuCl to different 1,7‐enynes and leads to structurally unique carbene–gold(I) complexes in high yields. These novel complexes are catalytically active and inhibit the proliferation of different human cancer cell lines. |
| Keywords: | carbenes cyclization enynes organometallic complexes |