Identification of a highly effective asymmetric phase-transfer catalyst derived from α-methylnaphthylamine |
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| Authors: | Barry LygoSRussell James |
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| Institution: | a School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK
b AstraZeneca, Process R&D, Silk Road Business Park, Charter Way, Macclesfield, Cheshire SK10 2NA, UK |
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| Abstract: | A library of quaternary ammonium salts has been generated via reaction of simple chiral amines with a series of conformationally dynamic biphenyl units. Screening of this library against the alkylation of a glycine imine has led to the identification of a highly effective asymmetric phase-transfer catalyst derived from α-methylnaphthylamine. |
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