|
|||||
|
|
Total synthesis and determination of the absolute configuration of (+)-neoisoprelaurefucin |
|
| Authors: | Hyunjoo LeeHyoungsu Kim Seungyoup BaekSanghee Kim Deukjoon Kim |
| Institution: | a Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, San 56-1, Shillim-Dong, Kwanak-Gu, Seoul 151-742, Republic of Korea b Natural Products Research Institute, College of Pharmacy, Seoul National University, 28 Yungun, Jongro-Ku, Seoul 110-460, Republic of Korea |
| Abstract: | The first total synthesis of the seven-membered ring ether marine natural product (+)-neoisoprelaurefucin (1) has been achieved employing a regioselective internal alkylation of amide 3, a novel sequence for removal of the triethylsilyl group from the resulting triethylsilyloxepene 2, and a bromoetherification of alcohol 16 as key steps. In addition, the absolute stereochemistry of the natural product was assigned. |
| Keywords: | internal alkylation total synthesis marine natural product seven-membered ether ring |
| 本文献已被 ScienceDirect 等数据库收录！ | |