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Solid-phase synthesis of natural product-like macrocycles by a sequence of Ugi-4CR and SNAr-based cycloetherification |
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| Authors: | Pierre CristauJean-Pierre Vors Jieping Zhu |
| Affiliation: | a Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France b Bayer CropScience, 14-20 Rue Pierre Baizet, 69009 Lyon, France |
| Abstract: | An on-resin Ugi four-component reaction followed by an intramolecular nucleophilic aromatic substitution (SNAr) has been developed for the rapid access to biaryl-ether containing macrocycles. |
| Keywords: | biaryl ether macrocycle multicomponent reaction SNAr cycloetherification solid-phase synthesis supported isocyanide |
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