Facile reduction of aromatic nitro/azido functionality on solid support employing Al/NiCl2·6H2O and Al/NH4Cl: synthesis of pyrrolo[2,1-c][1,4]benzodiazepines |
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| Authors: | Ahmed Kamal K.Laxma ReddyV. Devaiah G.Suresh Kumar Reddy |
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| Affiliation: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 007, India |
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| Abstract: | An efficient and mild method for the reduction of aromatic nitro and azido groups on solid support using Al/NiCl2·6H2O and Al/NH4Cl is described. This solid phase reduction technique has been applied towards the synthesis of DNA binding pyrrolo[2,1-c][1,4]benzodiazepine antitumour antibiotics. |
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