The first synthesis of the epoxide-containing macrolactone nucleus of oximidine I |
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| Authors: | Joanne E. HarveySteven A. Raw Richard J.K. Taylor |
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| Affiliation: | Department of Chemistry, University of York, Heslington, York YO10 5DD, UK |
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| Abstract: | A synthesis of the epoxydiene-containing macrolide nucleus of oximidine I is reported, starting from commercially available 3-butyn-1-ol. The key macrocyclisation step is achieved using Horner-Wadsworth-Emmons methodology in the presence of an epoxide. |
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| Keywords: | oximidine Horner-Wadsworth-Emmons epoxide |
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