Liquid-phase parallel synthesis of tetrahydro-β-carbolines |
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| Authors: | Wen-Ben YehMei-Jung Lin Chung-Ming Sun |
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| Affiliation: | Department of Chemistry, National Dong Hwa University, Hualien 974, Taiwan |
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| Abstract: | Parallel synthesis of β-carbolines on soluble polyethylene glycol (PEG-OH) support is demonstrated. One-pot condensation of polymer-bound tryptophan residues with various aldehydes and ketones has been carried out in the presence of p-TSA as a catalyst to deliver immobilized 1,2,3,4-tetrahydro-β-carbolines. Subsequent disengagement of the appendant from the polymer support afforded the desired products in good yield and acceptable purity. |
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