Asymmetric synthesis of (−)-acaterin |
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Authors: | Subba Rao V KandulaPradeep Kumar |
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Institution: | Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune 411008, India |
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Abstract: | The asymmetric synthesis of (−)-acaterin, an inhibitor of acyl-CoA cholesterol acyl transferase has been achieved starting from the commercially available starting materials, octan-1-ol and methyl (R)-lactate. The key steps are a Sharpless asymmetric dihydroxylation and a Wittig olefination. |
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