6,7,14,15-Tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole. Synthesis of a novel pentacyclic ring system |
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| Authors: | Kittisak SriphaDarius P. Zlotos Stefan BullerKlaus Mohr |
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| Affiliation: | a Pharmaceutical Institute, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
b Institute of Pharmacy, Dept. of Pharmacology and Toxicology, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany |
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| Abstract: | In search of new lead structures for potent allosteric enhancers of antagonist binding to muscarinic M2 receptors, a novel heterocyclic ring system, 6,7,14,15-tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole, has been synthesized. The new ring skeleton was obtained from indol-2-yl-acetic acid in three steps. |
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| Keywords: | 6,7,14,15-tetrahydro-15aH-azocino[1,2-a:6,5-b&prime ]diindole novel pentacyclic ring system ligands for the allosteric binding site of muscarinic M2 receptors dimerization of 2-(indol-2-yl)-ethyl tosylate intermolecular eight-ring formation via double alkylation |
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