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Bipyridyl-based diphosphine as an efficient ligand in the rhodium-catalyzed asymmetric conjugate addition of arylboronic acids to α,β-unsaturated ketones |
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| Authors: | Qian Shi Lijin XuXingshu Li Xian JiaRuihu Wang Terry T.-L. Au-YeungAlbert S.C. Chan Tamio Hayashi Rong CaoMaochun Hong |
| Affiliation: | a Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis††A University Grants Committee Area of Excellence in Hong Kong. and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China b Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan c State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, The Chinese Academy of Sciences, Fuzhou 325000, China |
| Abstract: | Reactions of α,β-unsaturated ketones with excess arylboronic acids in the presence of a rhodium catalyst generated in situ from Rh(acac)(C2H4) and (S)-P-Phos in dioxane/water at 100°C gave high yields of the corresponding products in up to 99% ee. |
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