Synthesis of carbo- and heterocycles via a palladium-catalysed allene insertion-nucleophile incorporation-Michael addition cascade |
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| Authors: | Xinjie GaiRonald Grigg Ines KöppenJohn Marchbank Visuvanathar Sridharan |
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| Institution: | Molecular Innovation, Diversity and Automated Synthesis (MIDAS) Centre, School of Chemistry, Leeds Univeristy, Leeds LS2 9JT, UK |
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| Abstract: | A novel palladium catalysed three-component cascade process is described involving allenylation of an aryl iodide to generate a (π-allyl)palladium species which is intercepted by a carbon or nitrogen nucleophile followed by intramolecular Michael addition to afford carbo- and heterocycles in good yield. |
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