Two-fold amino acid-based chiral aminophosphine-oxazolines and use in asymmetric allylic alkylation |
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| Authors: | Catherine BlancJé rô me Hannedouche,Francine Agbossou-Niedercorn |
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| Affiliation: | Laboratoire de Catalyse de Lille, UMR CNRS 8010, ENSCL, BP 108, 59652 Villeneuve d'Ascq Cedex, France |
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| Abstract: | Chiral aminophosphine-oxazoline ligands derived from two different amino acids (tetrahydroisoquinoline carboxylic acid and proline) have been synthesized and examined as chiral auxiliaries in asymmetric allylic alkylation of three substrates. Stereoisomers 1a and 2a are providing the highest enantioselectivities (up to 94% ee) in the allylation of diphenylpropenyl acetate. |
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