Isoindolinones via a room temperature palladium nanoparticle-catalysed 3-component cyclative carbonylation-amination cascade |
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| Authors: | Ronald Grigg Lixin ZhangSimon Collard Ann Keep |
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| Affiliation: | a Molecular Innovation, Diversity and Automated Synthesis (MIDAS) Centre, School of Chemistry, Leeds University, Leeds LS2 9JT, UK
b Johnson Matthey, Orchard Road, Royston, Herts SG8 5HE, UK |
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| Abstract: | A room temperature 3-component cascade process involving nucleophilic substitution/carbonylation/amination, catalysed by palladium nanoparticles generated in situ from palladacycle 5, affords isoindolinones in good yields. The conversions correlate with the pKa values of the amines. |
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