LiBF4: a mild and novel reagent for the OH insertion reactions of α-diazoketones |
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Authors: | JS Yadav BVS ReddyP Vishnumurthy |
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Institution: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 007, India |
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Abstract: | Lithium tetrafluoroborate (10 mol%) is found to catalyze efficiently the OH insertion reactions of α-diazoketones with various alcohols including benzylic, allylic, propargylic and cyclopropyl carbinols to produce the corresponding α-alkoxy ketones in excellent yields with high selectivity. A solution of 10 mol% of LiBF4 in acetonitrile provides a convenient reaction medium to carry out the OH insertion reactions under mild and neutral conditions. |
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Keywords: | α-diazoketones insertion reactions lithium salts α-alkoxy ketones |
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