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Efficient deprotection of N-benzyloxycarbonyl group from amino acids by hydroxyapatite-bound Pd catalyst in the presence of molecular hydrogen |
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| Authors: | Makoto MurataTakayoshi Hara Kohsuke MoriMasahiko Ooe Tomoo MizugakiKohki Ebitani Kiyotomi Kaneda |
| Institution: | Department of Chemical Science and Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan |
| Abstract: | Hydroxyapatite-bound Pd catalyst was found to be highly effective for the deprotection of N-benzyloxycarbonyl group from amino acids in the presence of molecular hydrogen. The catalyst was also applicable to the hydrogenolysis of a sterically encumbered core-Z-protected poly(amido amine) dendrimer, affording the dendritic amino compound in 99% yield. |
| Keywords: | hydrogenolysis benzyloxycarbonyl heterogeneous palladium catalyst hydroxyapatite dendrimer |
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